Author  
Place of duty  
Title   진행성 대장암에 대한 Leucovorin , 5-Fluorouracil 및 Cisplatin ( LV - FP ) 복합화학요법의 치료효과 ( Leucovorin , 5-Fluorouracil and Cisplatin ( LV - FP ) Chemotherapy for Advanced Colorectal Cancer )
Publicationinfo   1995 Jan; 027(01): 44-52.
Key_word   Advanced colorectal cancer, Leucovorin, 5-Fluorouracil, Cisplatin, Combination chemotherapy
Full-Text  
Abstract   The biochemical modulation of 5-fluorouracil(5-FU) by leucovorin has been demonstrated to enhance the activity of 5-FU in patients with advanced colorectal cancer and the synergism between 5-FU and cisplatin is well known in advanced gastrointestinal tract cancers. We conducted a phase II trial to evaluate the effect of a combination of leucovorin, 5-FU, and cisplatin(LV-FP) in patients with advanced colorectal cancer. LV-FP regimen consisted of leu- covorin 20 mg/m/day IV in day 1-5, 5-FU 1,000 mg/m/day continuous IV. infusion in day 1-5, and cisplatin 20 mg/m/day IV in day 1-5. The regimen was repeated every 3 weeks. Among 46 patients with histologically confirmed advanced colorectal adenocarcinoma, 31 patients had measurable lesion(s) with median age of 55 years(22-70 years). 27 patients had previous histo- ry of chemotherapy and l9 were previously untreated. There was no complete respanse. 11 patients responded partially to the regimen to make the response rate 35%(l1/31). The median time to progression was 16 weeks (2-44 weeks), and the median survival time was 42 weeks(l+~80 weeks). There was no difference in response rates between the previously treated and the previously untreated. Hematologic toxicities were mild and non-hematologic toxicities were also tolerable. There was no treatment-related mortality. These results indicate that the LV-FP regimen is safe and effective in advanced colorectal adenocarcinoma.
저 자   유영진(Young Jin Yuh),임영혁(Young Hyuck Im),강윤구(Yoon Koo Kang),김봉석(Bong Seog Kim),김형건(Hyung Gun Kim),손태용(Tae Yong Son),이상구(Sang Goo Lee),천온미(Eun Mee Cheon),김유철(You Cheoul Kim),김창민(Chang Min Kim),홍원선(Weon Seon Hong),이진오(Jhin Oh Lee),강태웅(Tae Woong Kang )